Volume 2, Issue 2, March 2014, Page: 15-19
Prevalence of Eosinophilic Esophagitis in Patients with Refractory Gastro-esophageal Reflux Disease Symptoms
Mohamed El malatawy, Internal Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Hanan Badawy, Internal Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Nanees Adel, Internal Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Behnam Tahmasebpour, Department of Agronomy and plant breeding, faculty of Agricultural Engineering and Technology, Collage of Agriculture and Natural resources, University of Tabriz, Tabriz, Iran
Reham Al Swaff, Internal Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Received: Feb. 16, 2014;       Published: Mar. 10, 2014
DOI: 10.11648/j.ajim.20140202.12      View  2838      Downloads  135
Abstract
Background and Aim: Eosinophilic esophagitis is an inflammatory disorder of the esophagus that is being increasingly diagnosed in the adult population. The present study aimed to determine the prevalence of eosinophilic esophagitis among Egyptian patients presenting with refractory GERD symptoms. Methods: 40 consecutive adult Egyptian patients with refractory GERD symptoms were enrolled in the study. Upper GIT endoscopy was done for all participants with at least 3 biopsies taken from 2 different sites in the esophagus including the distal and either mid or proximal esophagus even if the esophagus appeared endoscopically normal. Gastric and duodenal biopsies were also taken along with esophageal biopsies. All biopsies were examined histopathologically by blinded gastrointestinal pathologists. An esophageal eosinophilic count > 15/HPF, along with normal gastric and duodenal biopsies, substantiated the diagnosis of eosinophilic esophagitis. Results: The prevalence of eosinophilic esophagitis in this cohort was 2.5% (1/40). The affected participant was a 27 year old female patient who had a history of bronchial asthma (type 1 hypersensitivity reaction) for which she was treated with ,on demand, inhaled bronchodilators (short acting β agonist). The endoscopic examination of the affected participant showed furrows and plaques which are strongly suggestive of eosinophilic esophagitis. Conclusion: the low prevalence rate of eosinophilic esophagitis among the current small cohort of Egyptian patients with refractory GERD symptoms strongly mandates the search for additional data concerning the indications for esophageal biopsy in this subset of patients. History of atopy may warrant suspicion of eosinophilic esophagitis in this subset of patients.
Keywords
Eosinophilic, Esophagitis, Refractory, GERD
To cite this article
Mohamed El malatawy, Hanan Badawy, Nanees Adel, Behnam Tahmasebpour, Reham Al Swaff, Prevalence of Eosinophilic Esophagitis in Patients with Refractory Gastro-esophageal Reflux Disease Symptoms, American Journal of Internal Medicine. Vol. 2, No. 2, 2014, pp. 15-19. doi: 10.11648/j.ajim.20140202.12
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