Volume 6, Issue 6, November 2018, Page: 144-151
The Expression and Prognostic Value of NOX4 in Gastric Cancer
Lu Qiao, Department of Gastroenterology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China; Shaanxi Key Laboratory of Gastrointestinal Motility Disorders, Xi’an Jiaotong University, Xi'an, China
Ning Xie, Department of Gastroenterology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China; Shaanxi Key Laboratory of Gastrointestinal Motility Disorders, Xi’an Jiaotong University, Xi'an, China
Yuru Bai, Department of Gastroenterology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China; Shaanxi Key Laboratory of Gastrointestinal Motility Disorders, Xi’an Jiaotong University, Xi'an, China
Bin Qin, Department of Gastroenterology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China; Shaanxi Key Laboratory of Gastrointestinal Motility Disorders, Xi’an Jiaotong University, Xi'an, China
Baicang Zou, Department of Gastroenterology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China; Shaanxi Key Laboratory of Gastrointestinal Motility Disorders, Xi’an Jiaotong University, Xi'an, China
Yongquan Shi, Xijing Hospital of Digestive Diseases, Xijing Hospital of the Fourth Military Medical University, Xi'an, China
Yan Chen, Department of Oncology, Xijing Hospital of the Fourth Military Medical University, Xi'an, China
Na Liu, Department of Gastroenterology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China; Shaanxi Key Laboratory of Gastrointestinal Motility Disorders, Xi’an Jiaotong University, Xi'an, China
Jinhai Wang, Department of Gastroenterology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China; Shaanxi Key Laboratory of Gastrointestinal Motility Disorders, Xi’an Jiaotong University, Xi'an, China
Received: Aug. 1, 2018;       Accepted: Aug. 22, 2018;       Published: Oct. 12, 2018
DOI: 10.11648/j.ajim.20180606.11      View  272      Downloads  20
Abstract
Background: Gastric cancer (GC) is one of the most common malignant tumors worldwide which threaten the health of human. A lot of work has been done in tumor pathogenesis in recent years, while modest progress in diagnosis and treatment of gastric cancer have been made. Methods: Multiple databases including The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) were explored to identify the expression pattern of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4), the main source of reactive oxygen species, in gastric cancer. We also analyzed the correlation between the expression level of NOX4 and gastric cancer patients’ clinical features. The prognostic value of NOX4 was explored in TCGA and K-M Plotter. Last, we utilized TCGA and DAVID databases to uncover the underlying molecular mechanisms of NOX4 with TCGA and DAVID databases. Results: We found that NOX4 was upregulated in tumors compared with adjacent non-tumor tissues and overexpression was correlated with tumor invasion and TNM stage in gastric cancer. Furthermore, NOX4 level could be an independent prognostic marker for GC, unacted on the choice of therapy or HER2 expression. Besides, we investigated the potential mechanisms of NOX4 in gastric cancer. Conclusions: Our findings proved that NOX4 may be a new prognostic factor or therapeutic marker for gastric cancer.
Keywords
NOX4, Prognostic Values, Gastric Cancer
To cite this article
Lu Qiao, Ning Xie, Yuru Bai, Bin Qin, Baicang Zou, Yongquan Shi, Yan Chen, Na Liu, Jinhai Wang, The Expression and Prognostic Value of NOX4 in Gastric Cancer, American Journal of Internal Medicine. Vol. 6, No. 6, 2018, pp. 144-151. doi: 10.11648/j.ajim.20180606.11
Copyright
Copyright © 2018 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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