Volume 8, Issue 2, March 2020, Page: 51-56
Modern View on the Problem of Bronchial Asthma Comorbidity
Mykola Ostrovskyy, Department of Phthisiology and Pulmonology with the Course of Occupational Diseases, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine
Lilia Todoriko, Department of Phthisiology & Pulmonology, Higher State Educational Establishment “Bukovinian State Medical University”, Chernivtsi, Ukraine
Oleksandr Varunkiv, Department of Phthisiology and Pulmonology with the Course of Occupational Diseases, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine
Iryna Makoida, Department of Phthisiology and Pulmonology with the Course of Occupational Diseases, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine
Halyna Korzh, Department of Phthisiology and Pulmonology with the Course of Occupational Diseases, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine
Mariana Kulynych-Miskiv, Department of Phthisiology and Pulmonology with the Course of Occupational Diseases, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine
Liudmyla Babliuk, Department of Phthisiology and Pulmonology with the Course of Occupational Diseases, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine
Olha Molodovets, Department of Phthisiology and Pulmonology with the Course of Occupational Diseases, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine
Received: Dec. 24, 2019;       Accepted: Feb. 4, 2020;       Published: Mar. 2, 2020
DOI: 10.11648/j.ajim.20200802.11      View  60      Downloads  41
Abstract
We have examined 40 patients with bronchial asthma (BA) based at the municipal non-profit enterprise "Ivano-Frankivsk Regional Phthisiopulmonology Center of the Ivano-Frankivsk Regional Council" (Center for Pulmonary Diseases). The patients were randomized into two groups: Group I (17) involved patients with BA, Group II included (23) patients suffering from BA with obesity. The goal of the research work was to analyze the manifestations of clinical symptomatology, manageability of BA, state of pulmonary function, level of leptin in relation to mono- or polymorbidity. The research findings show the decrease in asthma manageability level in patients with combined pathology, particularly BA + obesity + gastroesophageal reflux disease (GERD), significant negative correlation (r=-0.95, p<0.001) between FEV1 and ACQ-5 data in patients suffering from BA with obesity and GERD. The frequency of nocturnal asthma attacks, heartburn, and sleep disorders tended to increase in patients with comorbid conditions. Features of changes in the concentration of leptin depending on the detected pathology is characterized by the following data. The level of leptin in patients with BA with and without obesity is 4.82 times higher as compared to patients with combined pathology (45.28 ± 10.42 ng/ml), and is significantly different (p<0.05) from the indices observed in patients with normal body weight (9.40 ± 1.52 ng/ml).
Keywords
Bronchial Asthma, Obesity, Spirometry, Polymorbidity
To cite this article
Mykola Ostrovskyy, Lilia Todoriko, Oleksandr Varunkiv, Iryna Makoida, Halyna Korzh, Mariana Kulynych-Miskiv, Liudmyla Babliuk, Olha Molodovets, Modern View on the Problem of Bronchial Asthma Comorbidity, American Journal of Internal Medicine. Special Issue: New Approaches to Manage Difficult-to-Control, Severe Asthma. Vol. 8, No. 2, 2020, pp. 51-56. doi: 10.11648/j.ajim.20200802.11
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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