Volume 8, Issue 3, May 2020, Page: 121-124
Leukemia B Lymphoblastic Lymphoma in a Child: With t (9.22) and Hyperdiploidy
Sophia Kahouli, Laboratory of Research and Medical Analysis of the Fraternal of the Royal Gendarmerie, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco
Hafid Zahid, Hematology-Immunohematology Service of the Military Instruction Hospital Mohammed V, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco
Saâd El kabbaj, Laboratory of Research and Medical Analysis of the Fraternal of the Royal Gendarmerie, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco
Majid Benkirane, Laboratory Center of the Military Instructional Hospital Mohammed V, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco
Nezha Messaoudi, Hematology-Immunohematology Service of the Military Instruction Hospital Mohammed V, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco
Received: Mar. 22, 2020;       Accepted: May 6, 2020;       Published: May 19, 2020
DOI: 10.11648/j.ajim.20200803.15      View  15      Downloads  14
Abstract
Introduction: Non-Hodgkin's lymphoblastic B lymphoma with lymph node location is exceptional in children. Unlike acute lymphoblastic leukemia, which is the first cancer in children around the age of 3 with a favorable prognosis with a survival of 5 years in 90%. Observation: child, 15 years old. The hospital admission examination showed a febrile patient (40°C), bilateral cervical and inguinal polyadenopathies, the absence of hepatosplenomegaly. The hemogram at entry found bicytopenia made up of angerogenic anemia and thrombocytopenia. On the haematological level, there has been an evolution towards pancytopenia. A lymph node biopsy showed medullary infiltration with lymphoma cells of phenotype B. The karyotype found hyper diploidy with t (9.22). The patient was put on corticosteroid therapy, hyperhydration and (Allopurinol) followed by COP type chemotherapy (Cyclophosphamide, Oncovin, Prednisone) with good tolerance. A year later the patient presented with a feverish peak (40°C). Only a hematological relapse in the form of acute leukemia. Therapeutically, it was decided to re-induce the patient according to the GRAALL catch-up protocol (Idarubicin-Aracytine) and to propose it for an allograft of bone marrow, but unfortunately the patient died. Conclusion: Lymphoblastic lymphoma / Acute lymphoblastic leukemia B, associated with t (9; 22) and hyperdiploidy in children is an exceptional hemopathy and has a negative diagnosis.
Keywords
Lymphoblastic Lymphoma, Acute Lymphoblastic Leukemia B, t (9.22), Hyperdiploidy, Child
To cite this article
Sophia Kahouli, Hafid Zahid, Saâd El kabbaj, Majid Benkirane, Nezha Messaoudi, Leukemia B Lymphoblastic Lymphoma in a Child: With t (9.22) and Hyperdiploidy, American Journal of Internal Medicine. Vol. 8, No. 3, 2020, pp. 121-124. doi: 10.11648/j.ajim.20200803.15
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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