Volume 8, Issue 3, May 2020, Page: 138-142
An Experimental Bacteriostasis of the Banxiaxiexin Decoction and 7 Kinds of Single Taste Traditional Chinese Medicine on Helicobacter Pylori Resistant Strains in Vitro
Zhiwei Qu, Department of Traditional Chinese Medicine, The Affiliated Hospital of Beihua University, Jilin, China
Mingjun Yu, Department of Gastroenterology, The Affiliated Hospital of Beihua University, Jilin, China
Airong Zhang, Department of Gastroenterology, The Affiliated Hospital of Beihua University, Jilin, China
Ailin Wang, Department of Laboratory Medicine, Beihua University, Jilin, China
Liyuan Shun, Department of Laboratory Medicine, Beihua University, Jilin, China
Received: Apr. 19, 2020;       Accepted: May 3, 2020;       Published: May 28, 2020
DOI: 10.11648/j.ajim.20200803.18      View  76      Downloads  43
Objectives: To research experimental bacteriostasis on the Banxiaxiexin decoction and 7 kinds of single taste Traditional Chinese Medicine (TCM) for Helicobacter pylori resistant strains in vitro. Methods: Collecting specimens of gastric mucosa in patients with upper gastrointestinal disease, separated and identified 8 strains of Hp resistant strains, the E-test methods of metronidazole and clarithromycin, drug resistance status of amoxicillin, selected eight strains of clinical drug resistance strains; Using liquid dilution method to determine the Banxiaxiexin decoction and 7 kinds of single Chinese medicine clinical drug-resistant strains of 8 strains of antibacterial effect in vitro. Results: Banxiaxiexin decoction MIC is 0.31 mg/ml, MIC of Radix scutellariae is 0.09 mg/ml, Rhizoma coptidis MIC 0. 16 mg/ml, Glycyrrhizin realness MIC 0. 31 mg/ml, Ginseng MIC 0. 75 mg/ml, there are four of seven kinds of single taste Traditional Chinese Medicine of TCM has bacteriostatic action, the order of antibacterial strength: Scutellaria baicalensis>Coptis chinesis>Glycyrrhizin realness >Ginseng, three kinds of Pinellia, Jujube and dry Zingibe in vitro for H. P ylori no inhibition, the method of MIC with liquid dilution in this decoction were determined, the decoction of resistant isolates average MIC isolates was 0.20±0.09mg/ml, the results showed that this decoction have stronger antibacterial effect on eight kinds of drug resistant strains in vitro. Banxiaxiexin decoction and 4kinds of single taste TCM have stronger antibacterial effect on drug resistant strains in vitro. Conclusion: Banxiaxiexin decoction and 4 kinds of single TCM have strong bacteriostatic effect on the bacteria resistance of Helicobacter pylori strains in vitro, therefore, we suggest that this decoction could be used as an effective method in the treatment of resistant HP associated gastritis.
Helicobacter Pylori, Drug Resistance, Banxiaxiexin Decoction, Bacteriostatic Effect
To cite this article
Zhiwei Qu, Mingjun Yu, Airong Zhang, Ailin Wang, Liyuan Shun, An Experimental Bacteriostasis of the Banxiaxiexin Decoction and 7 Kinds of Single Taste Traditional Chinese Medicine on Helicobacter Pylori Resistant Strains in Vitro, American Journal of Internal Medicine. Vol. 8, No. 3, 2020, pp. 138-142. doi: 10.11648/j.ajim.20200803.18
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