Volume 8, Issue 4, July 2020, Page: 148-152
Clinical Case with Negative Polymerase Chain Reaction (PCR) and Suspicious Chest Computed Tomography (CT) Images SARS-CoV-2 Infection or Not
Adjagba Philippe Mahouna, University Clinic of Cardiology, CNHU-HKM, University of Abomey-Calavi (UAC), Cotonou, Benin
Adjadohoun Sonia, University Clinic of Imaging and Radiodiagnostic, CNHU-HKM, University of Abomey-Calavi (UAC), Cotonou, Benin
Hounkponou Murielle, University Clinic of Cardiology, CNHU-HKM, University of Abomey-Calavi (UAC), Cotonou, Benin
Sonou Arnaud, University Clinic of Cardiology, CNHU-HKM, University of Abomey-Calavi (UAC), Cotonou, Benin
Codjo Léopold, University Clinic of Cardiology, CHUDBA, University of Parakou, Parakou, Benin
Soho Edson, Radiography, Ultrasound and Scanning Centre, Cotonou, Benin
Dahito Mickaella, University Clinic of Cardiology, CNHU-HKM, University of Abomey-Calavi (UAC), Cotonou, Benin
Avocèvou Géraud, University Clinic of Cardiology, CNHU-HKM, University of Abomey-Calavi (UAC), Cotonou, Benin
Djoh Ingrid, University Clinic of Cardiology, CNHU-HKM, University of Abomey-Calavi (UAC), Cotonou, Benin
Sissinto Yolande, University Clinic of Microbiology and Parasitology, CNHU-HKM, University of Abomey-Calavi (UAC), Cotonou, Benin
Yèkpè Patricia, University Clinic of Imaging and Radiodiagnostic, CNHU-HKM, University of Abomey-Calavi (UAC), Cotonou, Benin
Biaou Olivier, University Clinic of Imaging and Radiodiagnostic, CNHU-HKM, University of Abomey-Calavi (UAC), Cotonou, Benin
Houenassi Dèdonougbo Martin, University Clinic of Cardiology, CNHU-HKM, University of Abomey-Calavi (UAC), Cotonou, Benin
Received: May 12, 2020;       Accepted: May 28, 2020;       Published: Jun. 4, 2020
DOI: 10.11648/j.ajim.20200804.12      View  50      Downloads  59
Abstract
Background: The SARS-CoV-2 infection has polymorphic clinical presentations. The real time PCR is the reference diagnostic test; however, it can only detect presence of virus for a specific window of time. Case: We report a clinical case in a patient aged 66 years. His clinical history included known hypertension for 10 years and ischemic stroke. He had no known contact with infected persons. He initially presented with a productive cough, fever, shortness of breath on exertion, intense asthenia and palpitations. The real time PCR with upper airway samples was conducted on days 18 and 20 of the onset of symptoms and was negative. Despite chest CT abnormalities, the patient was not considered to be infected SARS-CoV-2 according to national recommendations for diagnosis and treatment in Benin. He was discharged from the treatment centre. Readmitted 7 days later to the emergency room for respiratory distress, the patient died. Conclusion. Diagnosis of SARS-CoV-2 infection can be difficult. In the context of typical clinical presentation, chest CT features of viral pneumonia may be strongly suspicious for SARS-CoV-2 despite negative real time PCR results. In order to improve the diagnostic and therapeutic strategy for SARS-CoV-2 infection in Benin, chest CT and other diagnostic tests/ criteria should be adopted.
Keywords
SARS-CoV-2, Real Time PCR, False Negative, Chest CT
To cite this article
Adjagba Philippe Mahouna, Adjadohoun Sonia, Hounkponou Murielle, Sonou Arnaud, Codjo Léopold, Soho Edson, Dahito Mickaella, Avocèvou Géraud, Djoh Ingrid, Sissinto Yolande, Yèkpè Patricia, Biaou Olivier, Houenassi Dèdonougbo Martin, Clinical Case with Negative Polymerase Chain Reaction (PCR) and Suspicious Chest Computed Tomography (CT) Images SARS-CoV-2 Infection or Not, American Journal of Internal Medicine. Vol. 8, No. 4, 2020, pp. 148-152. doi: 10.11648/j.ajim.20200804.12
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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